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Figure 4 3.1 Natural compounds 3.1.1 Phenolic Resveratrol showed a dose-dependent inhibition of TGF-β1-induced EMT-induced cell migration in the human MDA231 breast cancer cell line, decreased the expression levels of MMP-2 and MMP-9, and effectively inhibited MDA231 human breast cancer lung metastasis of cancer ( 3.1.2 Flavonoids Quercetin has a significant antitumor effect, inhibiting the proliferation of colon cancer by regulating the formation of ROS in a dose-dependent manner and attenuating the infiltration and hyperproliferation of inflammatory cells induced by DMH ( via the transfer of T-cell leukemia cells and inhibits TNF-α-induced NF-kB pathway activity ( 3.1.3 Terpenoids VEGF, as a vascular endothelial growth factor, can stimulate tumor angiogenesis, and andrographolide, As a kind of diterpenoid lactone, Andrographolide is good for the gallbladder, protects the liver, regulates the body’s immunity, and is used in meningitis, pneumonia, upper respiratory tract infection and has anti-tumor effect, inhibits angiogenesis through the VEGF pathway and inhibits the expression of COX-2 at the protein and mRNA levels
